Basic Information

Symbol
hsa-mir-4443
RNA class
miRNA miRNA hairpin
Alias
MIR4443 MicroRNA 4443 Hsa-Mir-4443 Hsa-MiR-4443 MIMAT0018961 MI0016786 Mir-4443
Location (GRCh38)
2:87629755-87629834
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4443
Sequence length
53 nt
GC content
0.5660

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-25.40 kcal/mol
Thermodynamic ensemble
Free energy: -26.17 kcal/mol
Frequency: 0.7005
Diversity: 1.23
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.(.(((((((((((.(((((((....))))))).))..))))))))).).).
Thermodynamic Ensemble Prediction
(.(.(((((((((((.(((((((....))))))).)),.})))))))).).).
Forensic Context

A study in human postmortem samples demonstrated that the mir-4443 was significantly increased (5.503-fold) in pericardial-fluid-derived exosomes from acute myocardial infarction subjects compared to controls, identifying it as a potential biomarker for this condition [Kim et al. DOI:10.3390/ijms25179619]. In a separate study on human newborns, the mir-4443 was found to be downregulated at 0–6 hours and upregulated at 7 days in the plasma of infants with perinatal asphyxia, indicating its potential as a dynamic biomarker for this hypoxic condition [Lai et al. DOI:10.1016/j.pedneo.2024.05.002].