Basic Information

Symbol
hsa-mir-4466
RNA class
miRNA miRNA hairpin
Alias
MIR4466 MicroRNA 4466 Hsa-Mir-4466 Hsa-MiR-4466 MIMAT0018993 MI0016817 Mir-4466
Location (GRCh38)
6:156779678-156779731
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4466
Sequence length
54 nt
GC content
0.8519

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.80 kcal/mol
Thermodynamic ensemble
Free energy: -39.70 kcal/mol
Frequency: 0.0455
Diversity: 6.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.(((((((((.((((.......)))).).)))))))))))).))).
Thermodynamic Ensemble Prediction
.(((((((.(((((((((.((((.{....,)))).)})))))))))))),})).
Forensic Context

A study in human astrocytes demonstrated that the mir-4466 is significantly down-regulated (Fold Change: -2.51) in extracellular vesicles after exposure to 3 Gy proton radiation, identifying it as a biomarker for neurological radiation injury [Gaines & Nestorova DOI:10.1016/j.lssr.2021.11.001]. Separately, an analysis of blood samples from human monozygotic twins found the mir-4466 to be differentially expressed and shared across two pairs of twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. A study in human astrocytes demonstrated that the mir-4466 is significantly down-regulated (Fold Change: -2.51) in extracellular vesicles after exposure to 3 Gy proton radiation, identifying it as a biomarker of neurological radiation injury [Deriesha Gaines; Gergana G. Nestorova DOI:10.1016/j.lssr.2021.11.001]. Separately, an analysis of human blood samples from monozygotic twins found the mir-4466 to be differentially expressed and shared across two pairs of twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao, Chao; Pan, Chao; Liu, Erliang; He, Huayu; Liu, Chunfeng; Huang, Yujie; Yi, Shaohua; Huang, Daixin DOI:10.1016/j.fsigen.2019.05.003].