Basic Information

Symbol
hsa-miR-4466
RNA class
miRNA mature miRNA
Alias
hsa-miR-4466 MIR4466 MicroRNA 4466
Location (GRCh38)
-
Forensic tag(s)
Individual identification Cause of death analysis
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-4466
Sequence length
18 nt
GC content
0.9444

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.80 kcal/mol
Thermodynamic ensemble
Free energy: -39.70 kcal/mol
Frequency: 0.0455
Diversity: 6.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((((((.(((((((((.((((.{....,)))).)})))))))))))),})).
Forensic Context

A study in human astrocytes demonstrated that the miR-4466 is significantly down-regulated (Fold Change: -2.51) in extracellular vesicles after exposure to 3 Gy proton radiation, identifying it as a biomarker for neurological radiation injury [Gaines & Nestorova DOI:10.1016/j.lssr.2021.11.001]. Separately, an analysis of blood samples from human monozygotic twins found the miR-4466 to be differentially expressed and shared across two pairs of twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. A study in human astrocytes demonstrated that the miR-4466 is significantly down-regulated (Fold Change: -2.51) in extracellular vesicles after exposure to 3 Gy proton radiation, identifying it as a biomarker of neurological radiation injury [Deriesha Gaines; Gergana G. Nestorova DOI:10.1016/j.lssr.2021.11.001]. Separately, an analysis of human blood samples from monozygotic twins found the miR-4466 to be differentially expressed and shared across two pairs of twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao, Chao; Pan, Chao; Liu, Erliang; He, Huayu; Liu, Chunfeng; Huang, Yujie; Yi, Shaohua; Huang, Daixin DOI:10.1016/j.fsigen.2019.05.003].