A study in humans demonstrated that the mir-4485 is upregulated six hours post-burn in heat-shocked skin epidermal stem cells compared to controls [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-4485 is upregulated in the blood of patients with major depressive disorder [Miguel et al. DOI:10.1089/Ars.2017.7175].