Basic Information

Symbol
hsa-mir-4488
RNA class
miRNA miRNA hairpin
Alias
MIR4488 MicroRNA 4488 Hsa-Mir-4488 Hsa-MiR-4488 MIMAT0019022 MI0016849 Mir-4488
Location (GRCh38)
11:61508596-61508657
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4488
Sequence length
62 nt
GC content
0.8226

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.70 kcal/mol
Thermodynamic ensemble
Free energy: -40.92 kcal/mol
Frequency: 0.1393
Diversity: 6.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in human myocardial autopsy specimens demonstrated that the mir-4488 was up-regulated in septic hearts compared to non-septic controls [Lehto et al. DOI:10.1038/s41598-024-81114-6]. In a separate human cell culture model, extracellular vesicles from irradiated astrocytes showed the mir-4488 was significantly down-regulated after 3 Gy proton radiation exposure [Gaines et al. DOI:10.1016/j.lssr.2021.11.001]. A study in human myocardial autopsy specimens demonstrated that the mir-4488 was up-regulated in the hearts of patients deceased with sepsis compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. In a separate human in vitro model, extracellular vesicles derived from irradiated astrocytes showed a significant down-regulation of the mir-4488 following 3 Gy proton radiation exposure [Deriesha Gaines et al. DOI:10.1016/j.lssr.2021.11.001].