Basic Information

Symbol
hsa-mir-449b
RNA class
miRNA miRNA hairpin
Alias
MIR449B MicroRNA 449b Hsa-MiR-449b-5p Hsa-Mir-449b MIRN449B Hsa-Mir-34-P3b_pre Hsa-MiR-449b-3p MIMAT0003327 MIMAT0009203 MI0003673 Mir-449b
Location (GRCh38)
1:162342546-162342640
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-449b
Sequence length
97 nt
GC content
0.4845

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.70 kcal/mol
Thermodynamic ensemble
Free energy: -37.25 kcal/mol
Frequency: 0.0812
Diversity: 13.04
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((.(((.(((((.(((((.(((..(((.(.((((((((.((......))))))))))))))))).)))))))))).))).))............
Thermodynamic Ensemble Prediction
...((.(((.(((((.(((((.(((,,(({.{.((((((({{((......)))))))))))))}))).)))))))))).))).))............
Forensic Context

A review of the literature establishes that the mir-449b is a hypoxamir repressed under hypoxic conditions, where it targets SERPINE1 to influence fibrotic pathways as part of the cellular adaptation to low oxygen tension [Nallamshetty et al. DOI:10.1016/j.freeradbiomed.2013.05.022]. A study in mice demonstrated that the mir-449b is downregulated in the cortex following traumatic brain injury and is related to secondary contusion expansion [Li et al. DOI:10.1016/j.neuint.2023.105643].