Forensic Context

A review of the literature establishes that the mir-449b is a hypoxamir repressed under hypoxic conditions, where it targets SERPINE1 to influence fibrotic pathways as part of the cellular adaptation to low oxygen tension [Nallamshetty et al. DOI:10.1016/j.freeradbiomed.2013.05.022]. A study in mice demonstrated that the mir-449b is downregulated in the cortex following traumatic brain injury and is related to secondary contusion expansion [Li et al. DOI:10.1016/j.neuint.2023.105643].