Basic Information

Symbol
hsa-mir-449c
RNA class
miRNA miRNA hairpin
Alias
MIR449C MicroRNA 449c Hsa-MiR-449c-5p Hsa-Mir-449c Hsa-Mir-34-P3a-V2_pre Hsa-Mir-34-P3a-V1_pre Hsa-MiR-449c-3p MIMAT0010251 MIMAT0013771 MI0003823 Mir-449c
Location (GRCh38)
2:207109987-207110073
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-449c
Sequence length
92 nt
GC content
0.4674

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.60 kcal/mol
Thermodynamic ensemble
Free energy: -45.68 kcal/mol
Frequency: 0.1737
Diversity: 5.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.((((((..((((.(((.((((((..(((((((((((((((.....)))))))))))))))))))))))).))))..))))))...)))
Thermodynamic Ensemble Prediction
,((.((((((..((((.(((.((((((..(((((((((((((((.....)))))))))))))))))))))))).))))..)))))),,.,},
Forensic Context

A study in mice demonstrated that the mir-449c was identified as an up-regulated known miRNA in thymus tissue following whole-body ionizing radiation exposure [Chen et al. DOI:10.1080/09553002.2016.1207821]. A review summarizing radiation biomarkers noted that the mir-449c is specifically expressed in spleen tissue and also in the kidney and small intestine, indicating its tissue-specific distribution [Jia et al. DOI:10.3389/fcell.2022.861451].