Basic Information

Symbol
hsa-mir-450a-1
RNA class
miRNA miRNA hairpin
Alias
MIR450A1 MicroRNA 450a-1 Hsa-MiR-450a-5p Hsa-Mir-450a-1 Hsa-Mir-450-1 Hsa-Mir-450 Hsa-MiR-450a-1-3p MicroRNA 450-1 MIRN450-1 MIRN450A1 MIRN450 Hsa-Mir-450-P2_pre MicroRNA 450 MIMAT0001545 MIMAT0022700 MIRN450A-1 Mir-450a-1 MI0001652 hsa-mir-450a
Location (GRCh38)
X:134540341-134540431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Sudden death from respiratory system disease Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-450a-1
Sequence length
91 nt
GC content
0.2747

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.70 kcal/mol
Thermodynamic ensemble
Free energy: -35.36 kcal/mol
Frequency: 0.3434
Diversity: 1.61
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((.(((((((...(((((.((((((((((((((.........)))))))))))))).)))))...))))))).)))))......
Thermodynamic Ensemble Prediction
....(((((.{((((((...(((((.((((((((((((((.........)))))))))))))).)))))...))))))}.)))))......
Forensic Context

A study in humans established a multi-class support vector machine (MSVM) classification model for forensic body fluid identification using TaqMan RT-qPCR, which achieved 98% accuracy on an independent test set and demonstrated efficacy on aged casework samples [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A study in rats demonstrated that the mir-450a was downregulated with a 1.67-fold change at 3 and 6 hours following oleic acid-induced acute lung injury [Lee et al. DOI:10.3892/Mmr.2014.2155]. A separate review noted that the mir-450a was differentially expressed in mouse blood 6 hours after γ-irradiation, indicating its potential as a radiation-responsive molecule [Jia & Wang DOI:10.3389/fcell.2022.861451].