Basic Information

Symbol
hsa-mir-450b
RNA class
miRNA miRNA hairpin
Alias
MIR450B MicroRNA 450b Hsa-MiR-450b-5p Hsa-Mir-450b MIRN450B Hsa-Mir-450-P3_pre Hsa-MiR-450b-3p MIMAT0004909 MIMAT0004910 MI0005531 Mir-450b
Location (GRCh38)
X:145994784-145994860
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Other applications Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-450b
Sequence length
78 nt
GC content
0.2821

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-22.80 kcal/mol
Thermodynamic ensemble
Free energy: -23.83 kcal/mol
Frequency: 0.1887
Diversity: 7.75
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((...(((((.(((.((((((((((.........)))).)))))).))).)))))...))))))))))..
Thermodynamic Ensemble Prediction
((((((((((...(((((.(((.(((({(((((.........}))),)))))).))).)))))...))))))))))..
Forensic Context

A study in humans demonstrated that the mir-450b was upregulated in plasma from patients with isolated traumatic spinal cord injury at emergency room admission compared to healthy controls, a finding validated by droplet digital PCR [Hörauf et al. DOI:10.3390/ijms262210954]. A study in rhesus macaques (Macaca mulatta) demonstrated that the mir-450b was utilized as a feature in a Day 6 three-group survival prediction model to forecast whether an animal would die in less than 90 days, between 90 and 269 days, or survive the 270-day study following whole thorax irradiation [May et al. DOI:10.1038/s41598-022-16316-x]. In human research, the mir-450b was identified as upregulated in venous ulcers compared to normal skin and acute wounds, and it was also upregulated 4 days post-burn in deep partial thickness burn skin versus normal skin [Siu et al. DOI:10.1111/wrr.13100].