Basic Information

Symbol
hsa-mir-124-1
RNA class
miRNA miRNA hairpin
Alias
MIR124-1 MicroRNA 124-1 Hsa-Mir-124a-1 Hsa-MiR-124-5p Hsa-Mir-124-1 MicroRNA 124a-1 MIRN124-1 MIRN124A1 Hsa-Mir-124-P2-V2_pre Hsa-Mir-124-P2-V1_pre Hsa-MiR-124-3p MIMAT0000422 MIMAT0004591 Mir-124-1 MI0000443 MIR124A1 MIR124A hsa-mir-124a
Location (GRCh38)
8:9903388-9903472
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-124-1
Sequence length
85 nt
GC content
0.5059

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.30 kcal/mol
Thermodynamic ensemble
Free energy: -36.22 kcal/mol
Frequency: 0.2249
Diversity: 3.11
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.((((((..(((..((((((((.(((..((((((((..........,,.))))))))..))).))))))))..)))..)))))).
Forensic Context

A study in human post-mortem brain tissues demonstrated that the mir-124-1 exhibited significantly higher expression levels in fatal traumatic brain injury cases compared to controls [Bonin et al. DOI:10.3390/ijms241310836]. A study in mice demonstrated that methamphetamine-induced locomotor sensitization involves significant downregulation of the mir-124-1 and other mature miRNAs in the nucleus accumbens, while their precursor levels remain unchanged or elevated, indicating a post-transcriptional regulatory mechanism via reduced Ago2-mediated splicing and increased Dicer1 expression [Liu et al. DOI:10.1111/Adb.12616].