Basic Information

Symbol
hsa-mir-124-3
RNA class
miRNA miRNA hairpin
Alias
MIR124-3 MicroRNA 124-3 Hsa-Mir-124a-3 Hsa-MiR-124-5p Hsa-Mir-124-3 MicroRNA 124a-3 MIRN124-3 MIRN124A3 Hsa-Mir-124-P3-V2_pre Hsa-Mir-124-P3-V1_pre Hsa-MiR-124-3p MIMAT0004591 MIMAT0000422 Mir-124-3 MI0000445
Location (GRCh38)
20:63178500-63178586
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Tissue/body fluid identification Drug abuse diagnoses
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-124-3
Sequence length
87 nt
GC content
0.5402

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.60 kcal/mol
Thermodynamic ensemble
Free energy: -41.98 kcal/mol
Frequency: 0.1064
Diversity: 4.96
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.((((..((((((((.(((..((((((((............))))))))..))).))))))))..)))).))).)))).
Thermodynamic Ensemble Prediction
.(((((((.(((({.((((((((.(((..((((((({...,,.....,.))))))))..))).))))))))}.)))).))).)))).
Forensic Context

A study in human traumatic brain injury (TBI) cases demonstrated that the mir-124-3 is a diagnostic biomarker, showing significantly higher expression in fatal TBI brain tissue compared to cardiovascular death controls [Bonin et al. DOI:10.3390/ijms241310836]. In forensic body fluid identification, the mir-124-3 exhibited its highest expression in vaginal secretion and was used in a validated qPCR-based algorithm, alongside hsa-miR-203a-3p, to differentiate vaginal secretion from saliva [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. In mice, the mir-124-3 is significantly downregulated in the nucleus accumbens of methamphetamine-sensitized animals, where it is identified as a Dicer1-targeting miRNA involved in addiction-related miRNA biogenesis pathways [Liu et al. DOI:10.1111/Adb.12616].