Basic Information

Symbol
hsa-mir-4508
RNA class
miRNA miRNA hairpin
Alias
MIR4508 MicroRNA 4508 Hsa-Mir-4508 Hsa-MiR-4508 MIMAT0019045 MI0016872 Mir-4508
Location (GRCh38)
2:110069961-110070042
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4508
Sequence length
70 nt
GC content
0.8000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.50 kcal/mol
Thermodynamic ensemble
Free energy: -39.35 kcal/mol
Frequency: 0.0494
Diversity: 32.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((.(((.((((.((((((((.(((..(((.(....).)))..))).))).)))))..))))..))))).
Thermodynamic Ensemble Prediction
.((.(((.(({,.||||||{(({({,.(({(((({{,,||)||),})))))))))).}))))..))))).
Forensic Context

A study in human myocardial autopsy specimens identified the mir-4508 as up-regulated in septic hearts compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. In a mouse model of traumatic brain injury with fracture, plasma exosomes containing the mir-4508 were found to be highly expressed and associated with promoting osteogenic activity [Yang et al. DOI:10.1016/j.jot.2021.09.003]. A study in humans identified mir-4508 as a top upregulated circulating microRNA in plasma from patients with acute myocardial infarction compared to non-AMI controls [Zhong et al. DOI:10.1002/jcla.23099].