Basic Information
Symbol
hsa-miR-4508
RNA class
miRNA
mature miRNA
Alias
hsa-miR-4508
MIR4508
MicroRNA 4508
Location (GRCh38)
-
Forensic tag(s)
Cause of death analysis
Mechanical injury analysis
Sudden cardiac death diagnosis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.50 kcal/mol
Thermodynamic ensemble
Free energy:
-39.35 kcal/mol
Frequency:
0.0494
Diversity:
32.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((.(((.((((.((((((((.(((..(((.(....).)))..))).))).)))))..))))..))))).
Thermodynamic Ensemble Prediction
.((.(((.(({,.||||||{(({({,.(({(((({{,,||)||),})))))))))).}))))..))))).
Forensic Context
A study in human myocardial autopsy specimens identified the miR-4508 as up-regulated in septic hearts compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. In a mouse model of traumatic brain injury with fracture, plasma exosomes containing the miR-4508 were found to be highly expressed and associated with promoting osteogenic activity [Yang et al. DOI:10.1016/j.jot.2021.09.003]. A study in humans identified miR-4508 as a top upregulated circulating microRNA in plasma from patients with acute myocardial infarction compared to non-AMI controls [Zhong et al. DOI:10.1002/jcla.23099].