Basic Information

Symbol
hsa-mir-4516
RNA class
miRNA miRNA hairpin
Alias
MIR4516 MicroRNA 4516 Hsa-Mir-4516 Hsa-MiR-4516 MIMAT0019053 MI0016882 Mir-4516
Location (GRCh38)
9:88745836-88745905
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4516
Sequence length
86 nt
GC content
0.7209

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.10 kcal/mol
Thermodynamic ensemble
Free energy: -44.61 kcal/mol
Frequency: 0.4342
Diversity: 12.30
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.(((.((((((.(((..(((...(((((((((.......)))))))))..)))..)).).)))))))))...)))))).
Thermodynamic Ensemble Prediction
.((((((.(((.((((((.(((..(((...(((((((((.......)))))))))..)))..)).}.)))))))))...)))))).
Forensic Context

A study in human astrocytes demonstrated that exposure to 3 Gy proton radiation significantly down-regulated the mir-4516 in extracellular vesicles, with a fold change of -3.11, identifying it as a biomarker for neurological radiation injury [Gaines et al. DOI:10.1016/j.lssr.2021.11.001]. A study in humans demonstrated that plasma exosomal miR-4516 levels were significantly higher in patients with acute myocardial infarction compared to healthy controls and exhibited high diagnostic efficiency with an AUC of 0.9809, also showing a positive correlation with coronary lesion complexity [Liu et al. DOI:10.3892/mmr.2023.13010]. Separately, research in human astrocytes found that extracellular vesicle-derived miR-4516 was significantly down-regulated following exposure to 3 Gy proton radiation, identifying it as a potential biomarker for neurological radiation injury [Gaines & Nestorova DOI:10.1016/j.lssr.2021.11.001].