Basic Information

Symbol
hsa-mir-452
RNA class
miRNA miRNA hairpin
Alias
MIR452 MicroRNA 452 Hsa-MiR-452-3p Hsa-MiR-452-5p Hsa-Mir-452 MIRN452 Hsa-Mir-452-V1_pre Hsa-Mir-452-V2_pre MIMAT0001636 MIMAT0001635 MI0001733 Mir-452
Location (GRCh38)
X:151959628-151959712
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-452
Sequence length
85 nt
GC content
0.4118

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.30 kcal/mol
Thermodynamic ensemble
Free energy: -42.13 kcal/mol
Frequency: 0.2605
Diversity: 2.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.((((((((((...(.((((((((.((.((((((((...........)))))))).)).)))))))).).)))))))))).))
Thermodynamic Ensemble Prediction
((.{(((((((((...(.((((((((.((.((((((((...........)))))))).)).)))))))).).)))))))))}.))
Forensic Context

A study in human skin fibroblast cell lines demonstrated that the mir-452 was upregulated 4 hours post-burn in heat-shocked fibroblasts compared to a sham group [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-452 was identified as a down-regulated known miRNA in thymus tissue following whole-body ionizing radiation exposure [Chen et al. DOI:10.1080/09553002.2016.1207821]. In rhesus macaques, the mir-452 was utilized as a feature in a survival prediction model at Day 9 and as a feature in a pleural effusion prediction model at Day 15, demonstrating its role in forecasting outcomes following thoracic irradiation [May et al. DOI:10.1038/s41598-022-16316-x].