Basic Information

Symbol
hsa-mir-4539
RNA class
miRNA miRNA hairpin
Alias
MIR4539 MicroRNA 4539 Hsa-Mir-4539 MIMAT0019082 Hsa-MiR-4539 MI0016910
Location (GRCh38)
4:143343460-143343535
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4539
Sequence length
60 nt
GC content
0.6333

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.20 kcal/mol
Thermodynamic ensemble
Free energy: -29.64 kcal/mol
Frequency: 0.4872
Diversity: 2.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.((((.(((((((((..((...))..))))))))).)))).).((.(((...))).)).
Thermodynamic Ensemble Prediction
{.((((.(((((((((..((...))..))))))))).)))).}.((.(((...))).)).
Forensic Context

A study in humans demonstrated that the mir-4539 was among 545 microRNAs differentially expressed between monozygotic twin pairs, being shared across three pairs of twins in blood samples, which suggests a role in distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. This finding, alongside the validation of other selected miRNAs by qRT-PCR, indicates a role for differential miRNA expression, including the mir-4539, in distinguishing genetically identical individuals for forensic identification.