Basic Information
Symbol
hsa-miR-4539
RNA class
miRNA
mature miRNA
Alias
hsa-miR-4539
MIR4539
MicroRNA 4539
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.20 kcal/mol
Thermodynamic ensemble
Free energy:
-29.64 kcal/mol
Frequency:
0.4872
Diversity:
2.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
{.((((.(((((((((..((...))..))))))))).)))).}.((.(((...))).)).
Forensic Context
A study in humans demonstrated that the miR-4539 was among 545 microRNAs differentially expressed between monozygotic twin pairs, being shared across three pairs of twins in blood samples, which suggests a role in distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. This finding, alongside the validation of other selected miRNAs by qRT-PCR, indicates a role for differential miRNA expression, including the miR-4539, in distinguishing genetically identical individuals for forensic identification.