Basic Information

Symbol
hsa-mir-454
RNA class
miRNA miRNA hairpin
Alias
MIR454 MicroRNA 454 Hsa-MiR-454-3p Hsa-MiR-454-5p Hsa-Mir-454 MIRN454 Hsa-Mir-130-P3b_pre MIMAT0003885 MIMAT0003884 MI0003820 Mir-454
Location (GRCh38)
2:56000714-56000795
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-454
Sequence length
115 nt
GC content
0.3913

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.00 kcal/mol
Thermodynamic ensemble
Free energy: -42.47 kcal/mol
Frequency: 0.0918
Diversity: 10.84
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((.((((((.((((((((((((((((((((((((.(((((....)))))...)))....)))))))))...)))))))))))).))))))...))....))))))).
Thermodynamic Ensemble Prediction
.(((((((((.((((((.((((((((((((((((((((({,({(((,,....,,,,,...,))}}}.)))))))))...)))))))))))).))))))...)}...,))))))).
Forensic Context

A study in rhesus macaques (Macaca mulatta) demonstrated that the mir-454 was identified as a dose-dependent marker, being significantly upregulated and one of 21 miRNAs significantly regulated in both genders at either dose over time following whole thorax irradiation, and it was validated by qRT-PCR showing upregulation at Day 6 compared to control [May et al. DOI:10.1038/s41598-022-16316-x]. In human sepsis research, the mir-454 was part of a constructed ceRNA network, where it was predicted to interact with the core gene IL1R2, which is upregulated in sepsis patients and negatively associated with 28-day survival [Zhang et al. DOI:10.1186/s12920-023-01460-8]. In humans, a study of older monozygotic twins found that the mir-454 was positively associated with activity of daily living strength scores in cross-sectional analysis, suggesting improved physical function with higher expression [La Grotta et al. DOI:10.1016/j.mad.2025.112099].