A study in humans demonstrated that the miR-455-5p is upregulated in venous ulcers compared to normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that plasma exosomes after traumatic brain injury (TBI) contained the miR-455-5p and promoted osteoblast proliferation and differentiation, enhancing fracture callus formation and osteogenic marker expression [Yang et al. DOI:10.1016/j.jot.2021.09.003].