Forensic Context

A study in human trauma patients demonstrated that the let-7e was more abundant in circulating T cells during the injury stage compared to the recovery stage according to next-generation sequencing, though this upregulation was not significant in subsequent RT-qPCR validation [Rau et al. DOI:10.2147/JIR.S375881]. A separate meta-analysis in humans with mild traumatic brain injury identified the let-7e as downregulated in plasma, where it targets 1387 genes and is part of deregulated signaling pathways [Matyasova et al. DOI:10.4149/gpb_2021038]. A study in humans demonstrated that the expression of the let-7e in bone tissue negatively correlates with increasing post-mortem interval (PMI), showing significantly different levels in samples from less than one month compared to longer PMIs, suggesting its utility for PMI estimation [Joo-Young Na 10.1016/j.jflm.2020.102049]. Research in mice identified the let-7e as a member of the Let-7 family predicting high-dose and high-risk radiation exposure, where it was an important component in accurate decision tree models for biodosimetry classification [Martello et al. 10.1667/RADE-23-00007.1].