Basic Information

Symbol
hsa-mir-1248
RNA class
miRNA miRNA hairpin
Alias
MIR1248 MicroRNA 1248 Hsa-Mir-1248 Hsa-MiR-1248 MIRN1248 MIMAT0005900 MI0006383 Mir-1248
Location (GRCh38)
3:186786672-186786777
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Chronological age estimation Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1248
Sequence length
106 nt
GC content
0.3774

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.50 kcal/mol
Thermodynamic ensemble
Free energy: -35.95 kcal/mol
Frequency: 0.0957
Diversity: 6.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).............
Thermodynamic Ensemble Prediction
..,..((((((((....{.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).,..))))))))....,,.......
Forensic Context

A review of human miRNA profiling for forensic body fluid identification notes that the mir-1248 is considered a pregnancy-associated biomarker detected in maternal plasma [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002] and is also reported as an age-related biomarker with significantly decreased expression in human serum with aging [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002]; in a separate review of human skin biology, the mir-1248 was found upregulated in venous ulcers versus normal skin and acute wounds and downregulated six hours post-burn in heat-shocked skin epidermal stem cells [Siu et al. DOI:10.1111/wrr.13100].