Basic Information
Symbol
hsa-miR-1248
RNA class
miRNA
mature miRNA
Alias
hsa-miR-1248
MIR1248
MicroRNA 1248
Location (GRCh38)
-
Forensic tag(s)
Chronological age estimation
Wound age identification
Other applications
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.50 kcal/mol
Thermodynamic ensemble
Free energy:
-35.95 kcal/mol
Frequency:
0.0957
Diversity:
6.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).............
Thermodynamic Ensemble Prediction
..,..((((((((....{.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).,..))))))))....,,.......
Forensic Context
A review of human miRNA profiling for forensic body fluid identification notes that the miR-1248 is considered a pregnancy-associated biomarker detected in maternal plasma [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002] and is also reported as an age-related biomarker with significantly decreased expression in human serum with aging [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002]; in a separate review of human skin biology, the miR-1248 was found upregulated in venous ulcers versus normal skin and acute wounds and downregulated six hours post-burn in heat-shocked skin epidermal stem cells [Siu et al. DOI:10.1111/wrr.13100].