Basic Information

Symbol
hsa-mir-4726
RNA class
miRNA miRNA hairpin
Alias
MIR4726 MicroRNA 4726 Hsa-MiR-4726-3p Hsa-Mir-4726 Hsa-MiR-4726-5p MIMAT0019846 MIMAT0019845 MI0017363
Location (GRCh38)
17:38719691-38719748
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Wound age identification Drug abuse diagnoses
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4726
Sequence length
58 nt
GC content
0.6724

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.70 kcal/mol
Thermodynamic ensemble
Free energy: -39.02 kcal/mol
Frequency: 0.1165
Diversity: 5.39
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like the mir-4726-5p showing altered expression in hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A separate forensic study in humans established a multi-class support vector machine model for body fluid identification using 12 key miRNA markers, though the mir-4726-5p was not among the evaluated markers in this validated workflow [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A systematic review of studies in humans, rats, mice, zebrafish, and macaques synthesized that the mir-4726-5p is downregulated in cocaine-exposed astrocytes and is part of the LINC01133-miR-4276-NDUFA9 axis [Occhipinti et al. DOI:10.3390/Ijms242317122].