Basic Information

Symbol
hsa-mir-125a
RNA class
miRNA miRNA hairpin
Alias
MIR125A MicroRNA 125a Hsa-MiR-125a-3p Hsa-MiR-125a-5p Hsa-Mir-125a MIRN125A Hsa-Mir-10-P3b_pre MIMAT0004602 MIMAT0000443 MiRNA125A MI0000469 Mir-125a
Location (GRCh38)
11:57641198-57641286
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-125a
Sequence length
86 nt
GC content
0.5930

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-46.20 kcal/mol
Thermodynamic ensemble
Free energy: -46.92 kcal/mol
Frequency: 0.3125
Diversity: 4.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(.((((((.(((((((.((((..((((((((((....))....)))))))))))).))))))).)))))).).))))).
Thermodynamic Ensemble Prediction
.(((((.(.((((((.(((((((.((((..(((((((({{....}}....)))))))))))).))))))).)))))).).))))).
Forensic Context

A study in humans demonstrated that the mir-125a was downregulated in plasma-derived exosomes from trauma patients compared to operative controls, where it is involved in hematopoiesis and immune function by inducing M2 macrophage polarization and regulating megakaryocytic proplatelet formation [Munley et al. DOI:10.1097/TA.0000000000004225]. Another human study found the mir-125a was markedly upregulated in trauma plasma and served as part of a diagnostic panel with strong predictive ability for trauma severity, organ injury, coagulation, endothelial activation, and inflammation [Ren et al. DOI:10.1016/j.isci.2025.113569]. A study in mice demonstrated that the mir-125a is substantially downregulated in ischemic heart tissue after coronary artery ligation, with its expression being less abundant post-ligation [Williams et al. DOI:10.1152/physiolgenomics.00041.2020].