Basic Information

Symbol
hsa-mir-4730
RNA class
miRNA miRNA hairpin
Alias
MIR4730 MicroRNA 4730 Hsa-Mir-4730 MIMAT0019852 Hsa-MiR-4730 MI0017367
Location (GRCh38)
8:27701673-27701767
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4730
Sequence length
76 nt
GC content
0.6579

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.60 kcal/mol
Thermodynamic ensemble
Free energy: -40.10 kcal/mol
Frequency: 0.4412
Diversity: 2.18
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
..(((((((.(((.(.(((.(((.(((.((((..(((...))).))))))).))).))).).))).)))))))...
Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the mir-4730 was significantly downregulated at a 1 Gy radiation dose, identifying it as a potential biomarker for radiation response [Lee et al. DOI:10.1155/2014/456323]. In a separate investigation using human umbilical vein endothelial cells, the mir-4730 was significantly downregulated in exosomes derived from cells exposed to heat stroke temperature conditions, with a fold change of 31.87, identifying it as a noninvasive biomarker for heat stroke [Chen et al. DOI:10.12659/MSM.909983]. A review summarizing research on microRNAs as markers of ionizing radiation injury noted that the mir-4730 was down-regulated in human PBMCs at 1 Gy 24h after irradiation, further supporting its role in dose estimation [Jia & Wang DOI:10.3389/fcell.2022.861451].