Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the miR-4730 was significantly downregulated at a 1 Gy radiation dose, identifying it as a potential biomarker for radiation response [Lee et al. DOI:10.1155/2014/456323]. In a separate investigation using human umbilical vein endothelial cells, the miR-4730 was significantly downregulated in exosomes derived from cells exposed to heat stroke temperature conditions, with a fold change of 31.87, identifying it as a noninvasive biomarker for heat stroke [Chen et al. DOI:10.12659/MSM.909983]. A review summarizing research on microRNAs as markers of ionizing radiation injury noted that the miR-4730 was down-regulated in human PBMCs at 1 Gy 24h after irradiation, further supporting its role in dose estimation [Jia & Wang DOI:10.3389/fcell.2022.861451].