Forensic Context

A study in mice demonstrated that the miR-125a-3p is significantly increased in ischemic heart tissue three days after myocardial infarction [Williams et al. DOI:10.1152/physiolgenomics.00041.2020]. In human trauma patients, plasma levels of the miR-125a-3p are markedly upregulated and correlate with injury severity and specific organ injury markers, showing strong diagnostic and predictive abilities for trauma [Ren et al. DOI:10.1016/j.isci.2025.113569]. Furthermore, research in mice has shown that the miR-125a-3p is differentially expressed in blood following ionizing radiation exposure, specifically within the intersection group of responses observed 24 hours after γ-irradiation and after ⁵⁶Fe ions irradiation [Jia & Wang DOI:10.3389/fcell.2022.861451].