Basic Information

Symbol
hsa-mir-4738
RNA class
miRNA miRNA hairpin
Alias
MIR4738 MicroRNA 4738 Hsa-MiR-4738-3p Hsa-Mir-4738 Hsa-MiR-4738-5p MIMAT0019867 MIMAT0019866 MI0017376
Location (GRCh38)
17:75784521-75784607
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4738
Sequence length
87 nt
GC content
0.5402

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-43.00 kcal/mol
Thermodynamic ensemble
Free energy: -45.06 kcal/mol
Frequency: 0.0356
Diversity: 12.76
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(..(((((((.....((((.((((((.(((((((((.(((((...)))))))))))))))))))))))))))))))).))))
Thermodynamic Ensemble Prediction
((((.(..(((((((.....((((.((((((((((((((((.(((({...}))))))))))))))))))))))))))))))),))))
Forensic Context

A review of human skin burns, wound healing, and scarring identified 197 miRNAs with altered expression, including the mir-4738-3p which was downregulated in hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. In a separate human study investigating coronary artery disease, the mir-4738-3p was downregulated in whole blood of patients with recurrent myocardial infarction compared to those without, with this association remaining significant after false-discovery rate correction [Onuoha et al. DOI:10.1111/cts.13307]. A study in humans demonstrated that the mir-4738-3p was differentially expressed across two pairs of monozygotic twins, suggesting its potential role as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].