Forensic Context

A study in human primary astrocytes demonstrated that the miR-4739 is significantly down-regulated (Fold Change: -2.48) in extracellular vesicles after exposure to 3 Gy proton radiation, identifying it as a biomarker of neurological radiation injury [Gaines et al. DOI:10.1016/j.lssr.2021.11.001]. In a separate human clinical study, the miR-4739 was found to be significantly down-regulated in the whole blood of patients with coronary artery disease who experienced recurrent myocardial infarction after percutaneous coronary intervention, establishing it as a biomarker for recurrent MI risk [Onuoha et al. DOI:10.1111/cts.13307]. In a separate in vitro study using human astrocytes, the miR-4739 was significantly downregulated in extracellular vesicles derived from cells exposed to 3 Gy proton radiation, indicating its potential as a biomarker for neurological radiation injury [Gaines & Nestorova DOI:10.1016/j.lssr.2021.11.001].