Basic Information

Symbol
hsa-mir-4743
RNA class
miRNA miRNA hairpin
Alias
MIR4743 MicroRNA 4743 Hsa-Mir-4743 Hsa-MiR-4743-5p Hsa-MiR-4743-3p MIMAT0019874 MIMAT0022978 MI0017381
Location (GRCh38)
18:48670600-48670668
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4743
Sequence length
69 nt
GC content
0.5362

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.50 kcal/mol
Thermodynamic ensemble
Free energy: -35.93 kcal/mol
Frequency: 0.0979
Diversity: 5.65
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in human cadavers demonstrated that exosomal miRNAs, including the mir-4743, are stably preserved in postmortem serum for at least three days when stored at or below 20°C [Kanno et al. DOI:10.1007/S00414-022-02913-Y]. A separate review of human skin biology reported that the mir-4743 is downregulated in hypertrophic scar tissue compared to normal skin, indicating its dysregulation in wound healing and scarring processes [Siu et al. DOI:10.1111/wrr.13100]. Furthermore, a review of thermal skin injury research listed the mir-4743 among miRNAs dysregulated in human hypertrophic scar tissue [Wang & Zhou DOI:10.1007/s00438-024-02183-w].