Forensic Context

A study in humans demonstrated that the miR-125a-5p was downregulated in plasma-derived exosomes from severe trauma patients compared to operative controls, and it is linked to hematopoiesis and immune function regulation, including inducing M2 macrophage polarization and regulating megakaryocytic proplatelet formation [Munley et al. DOI:10.1097/TA.0000000000004225]. Another study in humans found that the miR-125a-5p was markedly upregulated in plasma following trauma and, as part of a panel, possessed strong diagnostic and predictive abilities for trauma severity, organ injury, coagulation, endothelial activation, and inflammation [Ren et al. DOI:10.1016/j.isci.2025.113569]. A study in mice demonstrated that the miR-125a-5p is substantially downregulated in ischemic heart tissue after coronary artery ligation, and its expression inversely correlates with its target XIRP1, with luciferase reporter assays confirming a direct interaction with the FIH mRNA target [Williams et al. DOI:10.1152/physiolgenomics.00041.2020].