Basic Information

Symbol
hsa-mir-125b-1
RNA class
miRNA miRNA hairpin
Alias
MIR125B1 MicroRNA 125b-1 Hsa-MiR-125b-1-3p Hsa-MiR-125b-5p Hsa-Mir-125b-1 MIRN125B1 Hsa-Mir-10-P3d_pre MIMAT0004592 MIMAT0000423 Mir-125b-1 hsa-mir-125b MI0000446
Location (GRCh38)
19:10718404-10718503
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification Sudden cardiac death diagnosis Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-125b-1
Sequence length
88 nt
GC content
0.5341

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.10 kcal/mol
Thermodynamic ensemble
Free energy: -41.58 kcal/mol
Frequency: 0.4625
Diversity: 5.27
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..(((.((((.(((((((.(((((((((((..(((((.....))))).))))))))))).))))))).)))).)))..)))).
Thermodynamic Ensemble Prediction
.((((..(((.((((.(((((((.(((((((((((..(((((.....))))).))))))))))).))))))).)))).)))..)))).
Forensic Context

A study in humans demonstrated that the mir-125b is dysregulated in burn injury, wound healing, and scarring processes, with its expression in human skin tissue and fibroblasts showing both upregulation and downregulation at specific post-burn timepoints [Siu et al. DOI:10.1111/wrr.13100]. In human myocardial infarction, circulating levels of the mir-125b were significantly decreased in patient plasma compared to healthy controls, as validated by next-generation sequencing and RT-qPCR, identifying it as a potential diagnostic biomarker [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. A study in humans identified the mir-125b as a potential body fluid identification marker for saliva, as reported in published data [Liu et al. DOI:10.3390/genes13091530].