Basic Information
Symbol
hsa-miR-4748
RNA class
miRNA
mature miRNA
Alias
hsa-miR-4748
MIR4748
MicroRNA 4748
Location (GRCh38)
-
Forensic tag(s)
Individual identification
Mechanical injury analysis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.90 kcal/mol
Thermodynamic ensemble
Free energy:
-34.21 kcal/mol
Frequency:
0.0234
Diversity:
10.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((.((.(((((.(((.((((((..(.((....)).).)))))).))).))))).)))).))).......)))))
Thermodynamic Ensemble Prediction
{(((((((((.((,(((((.{((.((((((..{.((....)).,.)))))).))}.))))))),)).))).......))))}
Forensic Context
A study in humans identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the miR-4748 being one of the miRNAs downregulated in hypertrophic scar tissue compared to normal tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the miR-4748 was differentially expressed and shared across two pairs of monozygotic twins, as identified through miRNA microarray analysis of blood samples from 18 twin pairs, with the differential expression profiles validated by qRT-PCR for selected miRNAs, indicating its potential role as a biomarker for distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].