Basic Information

Symbol
hsa-mir-4754
RNA class
miRNA miRNA hairpin
Alias
MIR4754 MicroRNA 4754 Hsa-Mir-4754 MIMAT0019894 Hsa-MiR-4754 MI0017394 Mir-4754
Location (GRCh38)
19:58386770-58386858
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4754
Sequence length
89 nt
GC content
0.6966

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.50 kcal/mol
Thermodynamic ensemble
Free energy: -41.42 kcal/mol
Frequency: 0.0445
Diversity: 15.80
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((.....(((((((((((...((((((...(((...((((...)))).)))))))))...)))))))..))))))))........
Thermodynamic Ensemble Prediction
..((((.{{.,(((((((((((,,.((((((...(((...((((...)))).))))))))).,,))))))),.)))))))),.}}}}..
Forensic Context

A study in humans demonstrated that the mir-4754 was not investigated as a candidate marker for body fluid identification in the comprehensive forensic analysis, which instead validated a four-miRNA panel (hsa-miR-891a-5p, hsa-miR-144-3p, hsa-miR-203a-3p, hsa-miR-124-3p) for robustly identifying venous blood, saliva, semen, vaginal secretion, and menstrual blood in single-source and aged samples [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. A study in humans demonstrated that the mir-4754 was differentially expressed and shared across two pairs of monozygotic twins, with its expression profile analyzed via miRNA microarray and validated by qRT-PCR, indicating its potential as a biomarker for distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].