Forensic Context

A study in humans demonstrated that the miR-4772-5p is significantly upregulated in the blood of septic patients compared to those with systemic inflammatory response syndrome (SIRS) and healthy controls, and a linear discriminant analysis model combining it with miR-150 achieved an average diagnostic accuracy of 86% across independent cohorts [Ma et al. DOI:10.1371/journal.pone.0075918]. A separate human study identified the miR-4772-5p as part of a competing endogenous RNA regulatory network predicted to interact with core prognostic mRNA genes CD247, IL2RB, and TGFBR3 [Zhang et al. DOI:10.1186/s12920-023-01460-8]. A study in humans identified a combinatorial microRNA signature for sepsis diagnosis, where the miR-4772-5p was significantly upregulated in the blood of septic patients compared to those with systemic inflammatory response syndrome (SIRS) and healthy controls [Ma et al. DOI: 10.1371/journal.pone.0075918]. This biomarker, located in the IL-18RAP gene, was found to be differentially expressed in monocytes and upregulated in response to Toll-like receptor ligation, and a linear discriminant analysis model combining it with miR-150 achieved an average diagnostic accuracy of 86% across independent patient cohorts.