Basic Information

Symbol
hsa-mir-125b-2
RNA class
miRNA miRNA hairpin
Alias
MIR125B2 MicroRNA 125b-2 Hsa-MiR-125b-2-3p Hsa-MiR-125b-5p Hsa-Mir-125b-2 MIRN125B2 Hsa-Mir-10-P3c_pre MIMAT0000423 MIMAT0004603 Mir-125b-2 MI0000470
Location (GRCh38)
9:95085445-95085541
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-125b-2
Sequence length
89 nt
GC content
0.4944

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.80 kcal/mol
Thermodynamic ensemble
Free energy: -38.02 kcal/mol
Frequency: 0.0273
Diversity: 10.83
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((...((((.(((((((((.((((.(((.((((((((.((.........)).)))))))).))).)))))))).))))).)))).)).
Thermodynamic Ensemble Prediction
.((...((((.(((((((((.((((.(((.((((((((.{({,....,},,).)))))))).))).)))))))),})))).)))),),.
Forensic Context

A study in humans demonstrated that the mir-125b-2 is markedly upregulated in trauma plasma and contains pro-inflammatory motifs, with a panel including this biomarker distinguishing trauma from healthy controls with a cross-validated AUROC of 0.98 [Ren et al. DOI:10.1016/j.isci.2025.113569]. In human skin, the mir-125b-2 was found to be downregulated 4 days post-burn in deep partial thickness burn skin versus normal skin, though it was upregulated 4 hours post-burn in heat-shocked fibroblasts, and its transfection as a mimic promoted keratinocyte proliferation and migration [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-125b-2 was highly expressed in normal corporal tissue and its expression remained unchanged in a model of diet-induced erectile dysfunction [Barbery et al. DOI:10.1111/jsm.12793]. In human forensic samples, comprehensive small RNA profiling identified the mir-125b-2 as a potential body fluid identification marker for saliva, as reported in prior literature [Liu et al. DOI:10.3390/genes13091530].