Forensic RNA Knowledge Base

Basic Information

Symbol

hsa-mir-4791

RNA class

miRNA miRNA hairpin

Alias

MIR4791 MicroRNA 4791 Hsa-Mir-4791 Hsa-MiR-4791 MIMAT0019963 MI0017438 Mir-4791

Location (GRCh38)

3:19314848-19314931

UCSC Genome Browser Search in Marker Scope

Forensic tag(s)

Mechanical injury analysis Wound age identification Sudden cardiac death diagnosis Individual identification

External database

HGNC

NCBI

Ensembl

miRBase

RNAcentral

Sequence & Structure

Transcript ID

hsa-mir-4791

Sequence length

84 nt

GC content

0.3333

Secondary Structure

Generated by RNAfold

Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.

Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.

Minimum free energy

-24.20 kcal/mol

Thermodynamic ensemble

Free energy: -26.21 kcal/mol

Frequency: 0.9433

Diversity: 0.19

MFE Structure Visualization

Structure Prediction

MFE Structure Prediction

.....(((((((((..((((((..((((..(((((...(((....)))...))))).))))...))))))))))))))).....

Thermodynamic Ensemble Prediction

.,,..(((((((((..((((((..((((..{((((...,,(,,..,,},,,))))).))))...)))))))))))))))..,,.

Forensic Context

A review of human skin burns, wound healing, and scarring identified 197 miRNAs with altered expression, where the mir-4791 was not among those experimentally studied in the provided human tissue samples, cell lines, or functional assays [Siu et al. DOI:10.1111/wrr.13100]. A separate study in humans with coronary artery disease investigating circulating miRNAs for thrombotic risk did not identify the mir-4791 as a differentially expressed biomarker in plasma or whole blood associated with recurrent myocardial infarction [Onuoha et al. DOI:10.1111/cts.13307]. A study in humans demonstrated that the mir-4791 is differentially expressed between monozygotic twins, as microarray analysis of blood samples from 18 twin pairs identified it among 545 differentially expressed miRNAs and subsequent qRT-PCR validation confirmed its differential expression in 5 to 8 of the pairs depending on the fold-change threshold applied [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].