Forensic Context

A study in humans identified the miR-4795-3p as a candidate for vaginal secretion identification via miRNA microarray profiling, but it showed no specific amplification in pooled samples and was not further investigated as a final marker in the subsequent qPCR-based decision algorithm [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. In a separate human study on sudden unexplained death, a heterozygous deletion in the 3' UTR of the TBX3 gene, located on a predicted miRNA binding site for the miR-4795-3p, was validated to significantly increase upstream gene expression in a dual-luciferase reporter assay, identifying it as a candidate variant for SUD predisposition [Wang et al. DOI:10.007/s00414-024-03329-6]. A study in human monozygotic twins identified the miR-4795-3p as a differentially expressed microRNA shared across two pairs of twins, suggesting a role in distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].