Basic Information

Symbol
hsa-mir-483
RNA class
miRNA miRNA hairpin
Alias
MIR483 MicroRNA 483 Hsa-MiR-483-5p Hsa-MiR-483-3p Hsa-Mir-483 MIRN483 Hsa-Mir-483_pre MIMAT0002173 MIMAT0004761 MI0002467 Mir-483
Location (GRCh38)
4:8005301-8005381
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-483
Sequence length
76 nt
GC content
0.6053

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.10 kcal/mol
Thermodynamic ensemble
Free energy: -45.59 kcal/mol
Frequency: 0.0893
Diversity: 17.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((((((((((((((((.{(.,((((({(({........},}..})),)),)).)))))))))))))}))})))
Forensic Context

A study in mice and human keratinocytes demonstrated that the mir-483 is upregulated during wound healing, peaking at the final closure stage, where its overexpression inhibits keratinocyte migration and proliferation by directly targeting MK2, MKI67, and YAP1, while its antagonism sustains proliferation [Bertero et al. DOI:10.1096/fj.10-168401]. In a separate study using mouse models of acute myocardial infarction, the mir-483 was downregulated in the infarct region, and its overexpression under therapeutic hypothermia inhibited hypoxia-induced cardiomyocyte apoptosis, reduced infarct size, and improved cardiac function by directly targeting Cdk9 [Xue et al. DOI:10.1161/JAHA.122.026160].