Basic Information

Symbol
hsa-mir-486-1
RNA class
miRNA miRNA hairpin
Alias
hsa-mir-486 MIR486-1 MicroRNA 486-1 Hsa-MiR-486-3p Hsa-MiR-486-5p Hsa-Mir-486 MicroRNA 486 MIRN486 MIR486 Hsa-Mir-486_pre Hsa-Mir-486-1 MIMAT0004762 MIMAT0002177 Mir-486-1 MI0002470
Location (GRCh38)
8:41660441-41660508
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-486-1
Sequence length
68 nt
GC content
0.6324

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-48.60 kcal/mol
Thermodynamic ensemble
Free energy: -49.56 kcal/mol
Frequency: 0.2098
Diversity: 3.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans demonstrated that the mir-486 was significantly upregulated in serum from patients with mild traumatic brain injury at baseline compared to controls, with expression progressively reducing at 24 and 48 hours post-injury, identifying it as a sensitive and specific biomarker for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7]. In a separate forensic investigation, exosomal the mir-486 was significantly elevated in postmortem plasma-derived exosomes from individuals with high-grade coronary atherosclerosis, highlighting its potential as a predictive biomarker for coronary atherosclerosis progression in postmortem diagnostics [Kim et al. DOI:10.3390/ijms25179619]. Another study in humans established that the mir-486 is the second most abundant miRNA in blood and bloodstains, with expression stable under normal storage for up to five months and at 37°C, though it was significantly down-regulated by freeze-thaw cycles and oxidant treatment [Fang et al. DOI:10.1016/j.fsigen.2018.10.001].