Basic Information

Symbol
hsa-mir-486-2
RNA class
miRNA miRNA hairpin
Alias
MIR486-2 MicroRNA 486-2 Hsa-MiR-486-5p Hsa-MiR-486-3p MicroRNA Mir-486-2 MIMAT0002177 MIMAT0004762 MI0023622 hsa-mir-486b MIR486B MicroRNA 486b Hsa-MiR-486b-3p Hsa-MiR-486b-5p
Location (GRCh38)
8:41660444-41660507
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-486-2
Sequence length
64 nt
GC content
0.6406

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-49.20 kcal/mol
Thermodynamic ensemble
Free energy: -50.15 kcal/mol
Frequency: 0.2126
Diversity: 3.10
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((((((((((((((((...((...))...)).))))))))))))))))))))))..
Thermodynamic Ensemble Prediction
((((((((((((((((((((((((...({...})...))}})))))))))))))))))))))..
Forensic Context

A study in humans demonstrated that the mir-486 was significantly upregulated in serum from patients with mild traumatic brain injury at baseline compared to controls, with expression progressively reducing at 24 and 48 hours post-injury, identifying it as a sensitive and specific biomarker for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7]. In a separate forensic investigation, exosomal the mir-486 was significantly elevated in postmortem plasma-derived exosomes from individuals with high-grade coronary atherosclerosis, highlighting its potential as a predictive biomarker for coronary atherosclerosis progression in postmortem diagnostics [Kim et al. DOI:10.3390/ijms25179619]. Another study in humans established that the mir-486 is the second most abundant miRNA in blood and bloodstains, with expression stable under normal storage for up to five months and at 37°C, though it was significantly down-regulated by freeze-thaw cycles and oxidant treatment [Fang et al. DOI:10.1016/j.fsigen.2018.10.001].