Basic Information

Symbol
hsa-mir-487b
RNA class
miRNA miRNA hairpin
Alias
MIR487B MicroRNA 487b Hsa-Mir-487b Hsa-MiR-487b-3p MIRN487B Hsa-Mir-154-P17_pre Hsa-MiR-487b-5p MIMAT0003180 MIMAT0026614 MI0003530 Mir-487b
Location (GRCh38)
X:134540508-134540607
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-487b
Sequence length
84 nt
GC content
0.4405

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.10 kcal/mol
Thermodynamic ensemble
Free energy: -35.60 kcal/mol
Frequency: 0.0876
Diversity: 4.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.(((((((((....((((((.(.(((((............))))).).))))))....))))))))).))))))).
Thermodynamic Ensemble Prediction
,(((((((.(((((((((....((((((.(.(((((....,,....},))))).).))))))....))))))))).))))))),
Forensic Context

A study in human patients with coronary artery disease identified the mir-487b as a biomarker for recurrent myocardial infarction risk, finding it was downregulated in whole blood of patients with recurrent MI after percutaneous coronary intervention, though it was not significantly different in plasma [Onuoha et al. DOI:10.1111/cts.13307]. Another study in human myocardial biopsies found the mir-487b was upregulated in volume overload cardiomyopathy compared to ischemic cardiomyopathy, and its differential expression was validated by qRT-PCR [Bonet et al. DOI:10.3390/biom14050524]. In a separate human study of older monozygotic twins, longitudinal analysis of plasma miRNAs associated the mir-487b with age-related functional decline, showing a negative beta coefficient indicating decreased functionality over time with higher baseline levels [La Grotta et al. DOI:10.1016/j.mad.2025.112099].