Basic Information

Symbol
hsa-mir-488
RNA class
miRNA miRNA hairpin
Alias
MIR488 MicroRNA 488 Hsa-MiR-488-5p Hsa-MiR-488-3p Hsa-Mir-488 MIRN488 Hsa-Mir-488_pre MIMAT0002804 MIMAT0004763 MI0003123 Mir-488
Location (GRCh38)
1:177029363-177029445
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-488
Sequence length
83 nt
GC content
0.3976

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.20 kcal/mol
Thermodynamic ensemble
Free energy: -32.78 kcal/mol
Frequency: 0.3910
Diversity: 3.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.((((((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..)))))).))))
Thermodynamic Ensemble Prediction
((((.((((((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..)))))).))))
Forensic Context

A systematic review of the literature on substance abuse indicates that the mir-488 is downregulated in the context of acute cocaine use in an Ago2-dependent manner, a finding based on studies in murine models, and is implicated in neural plasticity and motivation [Occhipinti et al. DOI:10.3390/Ijms242317122].