Basic Information

Symbol
hsa-mir-489
RNA class
miRNA miRNA hairpin
Alias
MIR489 MicroRNA 489 Hsa-Mir-489 Hsa-MiR-489-3p MIRN489 Hsa-Mir-489-V1_pre Hsa-Mir-489-V2_pre Hsa-MiR-489-5p MIMAT0026605 MIMAT0002805 MI0003124 Mir-489
Location (GRCh38)
7:129774905-129775014
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-489
Sequence length
84 nt
GC content
0.4762

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.20 kcal/mol
Thermodynamic ensemble
Free energy: -39.18 kcal/mol
Frequency: 0.2048
Diversity: 4.96
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((.(((((.(((((((((((((.(.((((..(((((....))))))))).).))))))))))))).))))).)))))))
Thermodynamic Ensemble Prediction
(((((((.(((((.(((((((((((((.(.((((..(((((....))))))))).).))))))))))))).))))).)))))))
Forensic Context

A study in humans demonstrated that the mir-489 was significantly decreased (0.496 of control, p=0.0113) in the postmortem prefrontal cortex of antidepressant-free depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. In separate human skin research, the mir-489 was downregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in rhesus macaques (Macaca mulatta) demonstrated that the mir-489 was identified as a feature in a Day 21 four-group survival prediction model following whole thorax irradiation [May et al. DOI:10.1038/s41598-022-16316-x]. A review of human postmortem brain studies reported that the mir-489 was downregulated in the Brodmann area 9 of subjects with major depressive disorder who died by suicide [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893].