Basic Information

Symbol
hsa-mir-490
RNA class
miRNA miRNA hairpin
Alias
MIR490 MicroRNA 490 Hsa-MiR-490-3p Hsa-MiR-490-5p Hsa-Mir-490 MiR-490 MIRN490 Hsa-Mir-490_pre MIMAT0002806 MIMAT0004764 MI0003125
Location (GRCh38)
7:136903167-136903294
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Drug abuse diagnoses Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-490
Sequence length
128 nt
GC content
0.5156

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-52.80 kcal/mol
Thermodynamic ensemble
Free energy: -56.25 kcal/mol
Frequency: 0.0037
Diversity: 16.36
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((..((((((.(((((((........((((((((.(((((((((((((((.(((((..........)).))).)))))))))..)))))).))))))))..))).))))))))))...))))))
Thermodynamic Ensemble Prediction
{(((((..{(((({,(((((((.....,..((((((((.(((((((((((((((.((({,.,{.......)).))).)))))))))..)))))).)))))))),,))).))))))))))...)))))}
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs showing altered expression in human skin tissue samples post-burn, during healing, and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the mir-490-3p expression in the nucleus accumbens increased by 121% in the chronic methamphetamine treatment group compared to the acute treatment group [Sim et al. DOI:10.1007/S11011-017-0061-X]. In a separate investigation, plasma exosomal miR-490-5p, a related miRNA, was identified as a biomarker for early acute myocardial infarction in rats and humans, with its expression showing an increasing trend within 30 minutes post-AMI and being upregulated 1.88 times in human AMI plasma exosomes, contributing to a high-precision identification model [Zhou et al. DOI:10.007/s00414-025-03583-2].