Basic Information

Symbol
hsa-mir-491
RNA class
miRNA miRNA hairpin
Alias
MIR491 MicroRNA 491 Hsa-MiR-491-5p Hsa-MiR-491-3p Hsa-Mir-491 MIRN491 Hsa-Mir-491_pre MIMAT0002807 MIMAT0004765 MI0003126 Mir-491
Location (GRCh38)
9:20716105-20716188
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-491
Sequence length
84 nt
GC content
0.5119

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-48.00 kcal/mol
Thermodynamic ensemble
Free energy: -48.86 kcal/mol
Frequency: 0.2467
Diversity: 2.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((((((((((.((((((..(((.((((((((((.....)))))))))).))).)))))).)))))))))))))))..
Thermodynamic Ensemble Prediction
.{(((((((((((((((.((((((..(((.((((((((((.....)))))))))).))).)))))).)))))))))))))))}.
Forensic Context

A study in rhesus macaques (Macaca mulatta) demonstrated that the mir-491 was utilized as a feature in a three-group survival prediction model at Day 3 post-thoracic irradiation, which achieved 71% accuracy in forecasting whether an animal would die in less than 90 days, between 90 and 269 days, or survive the 270-day study [May et al. DOI:10.1038/s41598-022-16316-x]. In a separate review of traumatic brain injury models, the mir-491 was identified as a therapeutic target where its inhibition was found to improve prognosis [Li et al. DOI:10.1016/j.neuint.2023.105643].