Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns in human skin tissue and cells post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the miR-491-3p is significantly upregulated in the peripheral blood of patients with sepsis compared to healthy controls and shows a positive correlation with proinflammatory cytokine levels and TDAG8/TLR4 mRNA expression, with ROC analysis indicating high diagnostic value [Xu et al. DOI:10.3892/mmr.2022.12850]. Separately, research in human monozygotic twins identified the miR-491-3p as a differentially expressed microRNA shared across four pairs of twins, suggesting its potential role in distinguishing genetically identical individuals for forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].