Basic Information

Symbol
hsa-mir-494
RNA class
miRNA miRNA hairpin
Alias
MIR494 MicroRNA 494 Hsa-Mir-494 Hsa-MiR-494-3p MIRN494 Hsa-Mir-154-P18_pre Hsa-MiR-494-5p MIMAT0026607 MIMAT0002816 MI0003134 Mir-494
Location (GRCh38)
14:101029634-101029714
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-494
Sequence length
81 nt
GC content
0.3827

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.90 kcal/mol
Thermodynamic ensemble
Free energy: -34.84 kcal/mol
Frequency: 0.2184
Diversity: 4.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((((.((((((((((((.((((((((((.(((((.........)).)))))).))))))).))))))))))))))))))
Forensic Context

A study in human postmortem prefrontal cortex demonstrated that the mir-494 was significantly decreased (0.535 of control, p=0.0174) in depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. In human skin research, the mir-494 was upregulated in hypertrophic scar fibroblasts compared to normal fibroblasts and was also upregulated in heat-shocked skin epidermal stem cells [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-494 is a differentially expressed microRNA in response to ionizing radiation-induced thymus injury, where it was identified as a down-regulated known miRNA in the irradiated thymus [Chen et al. DOI:10.1080/09553002.2016.1207821]. In a separate forensic investigation using mouse drowning models, the mir-494 (specifically mmu-miR-494-3p) was identified as one of eight specific miRNAs up-regulated in freshwater drowning and down-regulated in saltwater drowning according to microarray analysis, with predicted brain targets including POU3F2, TRIM44, and TRANK1 [Yu et al. DOI:10.1016/j.forsciint.2015.06.011].