Forensic Context

A study in humans demonstrated that the miR-494-3p is upregulated in hypertrophic scar tissue and its derived fibroblasts compared to normal skin fibroblasts following burn injury [Siu et al. DOI:10.1111/wrr.13100]. In a separate human trauma cohort, plasma-derived exosomes from male patients with severe injury showed significant downregulation of the miR-494-3p compared to operative controls, with this miRNA being involved in hematopoiesis [Munley et al. DOI:10.1097/TA.0000000000004225]. A study in mice demonstrated that the miR-494-3p is a potential biomarker of drowning, as its expression increased in brain tissue in a freshwater drowning model and decreased in a seawater drowning model [Song et al. DOI:10.1007/s00414-023-03091-1]. In human cardiac tissue, research identified the miR-494-3p as upregulated in volume overload cardiomyopathy compared to ischemic cardiomyopathy, where it forms a negatively correlated pair with SGMS2, a direct interaction validated by luciferase assay [Bonet et al. DOI:10.3390/biom14050524].